The R-BIND dataset was updated to include 22 new small molecules
and 13 new large molecules. Two preexisting small molecules were
updated to include an additional target. In preparation.
The R-BIND dataset was updated to included new categories
containing 153 small molecules (14 previously multivalent ligands,
and 41 new ligands) and 35 large molecules (28 previously
multivalent ligands, and 7 new ligands). One preexisting small
molecule was updated to include a second target. Donlic, A.;
Swanson, E.G.; Chiu, L-Y.; Wicks, S.L.; Umuhire Juru, A.; Cai, Z.;
Kassam, K.J.; Laudeman, C.; Sanaba, B.G.; Sugarman, A.; Han, E.;
Tolbert, B.S.; Hargrove, A.E. “R-BIND 2.0: An Updated Database of
Bioactive RNA-Targeting Small Molecules and Associated RNA
Secondary Structures.”
ACS Chem. Biol.
2022,
17 (6), 1556-1566.
DOI: 10.1021/acschembio.2c00224
The R-BIND dataset was updated to include 17 new small molecules
and 1 multivalent ligand. 4 preexisting small molecules and 1
preexisting multivalent ligand were updated to include a second
target. Morgan, B.S.; Sanaba, B.; Donlic, A.; Karloff, D.B.;
Forte, J.E.; Zhang, Y.; Hargrove, A.E. “R-BIND: An Interactive
Database for Exploring and Developing RNA-Targeted Chemical
Probes.”
ACS Chem. Biol.
2019,
14 (12), 2691-2700.
DOI: 10.1021/acschembio.9b00631
The R-BIND dataset was updated to include 8 new small molecules
and 4 multivalent ligands. Morgan, B. S.; Forte, J. E.; Hargrove,
A. E., Insights into the development of chemical probes for RNA.
Nucleic Acids Res.
2018,
46 (16), 8025-8037.
DOI: 10.1002/anie.201707641
The R-BIND dataset initially contained 67 small molecules and 37
multivalent ligands. This work was published in Morgan, B.S.;
Forte, J.E.; Culver, R.N.; Zhang, Y.; Hargrove, A.E. "Discovery of
Key Physicochemical, Structural, and Spatial Properties of
RNA-targeted Bioactive Ligands."
Angew. Chem. Int. Ed.
2017,
56, 13498-13502.
DOI: 10.1002/anie.201707641
