To be considered an R-BIND ligand, the molecule should follow these guidelines:
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have activity in cell culture and/or animal models;
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not be an aminoglycoside, peptide, oligonucleotide, or known nucleic acid intercalator;
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have evidence of binding to the target in vitro;
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have a molecular weight < 2,000 Da;
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target RNA through only non-covalent interactions;
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target a non-ribosomal RNA; and
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be highlighted by the author in the manuscript text as being particularly potent or having a notable activity cut-off.
Exceptions to individual criteria are made on a case-by-case basis.
